PROJECTION STRUCTURE OF A GAP JUNCTION MEMBRANE CHANNEL AT 7 ANGSTROMRESOLUTION

Authors
UNGER VM KUMAR NM GILULA NB YEAGER M
Citation
Vm. Unger et al., PROJECTION STRUCTURE OF A GAP JUNCTION MEMBRANE CHANNEL AT 7 ANGSTROMRESOLUTION, Nature structural biology, 4(1), 1997, pp. 39-43
Citations number
43
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
1
Year of publication
1997
Pages
39 - 43
Database
ISI
SICI code
1072-8368(1997)4:1<39:PSOAGJ>2.0.ZU;2-0
Abstract
Electron cryo-microscopy and image analysis of frozen-hydrated, two-di mensional crystals of gap junction membrane channels formed by recombi nant alpha(1) connexin (Cx43) reveal a ring of transmembrane alpha-hel ices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.