PARANEOPLASIC SUPERIOR VENA-CAVA THROMBOS IS EXHIBITING AN OVARIAN TUMOR

We report the case of a patient who was admitted in hospital for evalu ation of a superior vena cava thrombosis. The patient exhibited an act ivated protein C resistance due to an arginine-506 mutation in factor V. thoracic CT-scan showed a non-compressive complete superior vena ca va thrombosis. Other investigations revealed a pleural effusion associ ated with an ovarian tumor. Pathological data of pleural biopsies show ed a papillar carcinoma. Ovarian neoplasia revealed by a paraneoplasic syndrom was diagnosed. Treatment associated cyclophosphamide and carb oplatin with anti-K-vitamin was administrated, with a complete remissi on and disappearance of superior vena cava thrombosis at 27 months of evolution. At this date, we observed a local pelvis recurrence which w as treated with paclitaxel associated with surgery.