CHEMICAL AND PHARMACOLOGICAL STUDY OF HYG NER FUNGI .1. CHEMICAL-COMPOSITION AND PHARMACOLOGICAL INVESTIGATION CARPOPHORES CORTINARIUS-ARMILLATUS (FR-FR) FR (CORTINARIACEAE)

The fruit bodies of Cortinarius armillatus were investigated for polyo ls, tree sugars and amino acids, phenolic acids, alkaloids, nitrogen c ontent compounds, glycosides and fungal toxins using thin-layer chroma tography and qualitative chemical reactions. Arabitol, mannitol, treha lose, fructose, 4-hydroxybenzoic acid, cholin, alanine, proline, serin e, asparagine, glycosides and cortinarin A were detected in aqueous an d methanolic extracts from the mushroom. Valine, methionine, glutamini c acid and fungal toxins (alpha-amanitin, orellanine, muscarine, musci mol, bufotenine) were not observed within C. armillatus. The single in traperitoneal doses of the methanolic extract from C. armillatus have not been toxic and no induced effects organic pathology up to 2000 mg/ kg two weeks after injection to mice. These chemical studies and acute toxicity investigations supported the non-toxicity of C. armillatus. At the content of some chemical substances (4-hydroxybenzoic acid, cho lin, steroid glycosides, cortinarin A) this species may be perspective for a further pharmacological investigations.