MECHANISM OF INTERFERON ACTION - SEQUENCE OF THE HUMAN INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN-KINASE (PKR) DEDUCED FROM GENOMIC CLONES

Authors
KUHEN KL SHEN XY SAMUEL CE
Citation
Kl. Kuhen et al., MECHANISM OF INTERFERON ACTION - SEQUENCE OF THE HUMAN INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN-KINASE (PKR) DEDUCED FROM GENOMIC CLONES, Gene, 178(1-2), 1996, pp. 191-193
Citations number
12
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
178
Issue
1-2
Year of publication
1996
Pages
191 - 193
Database
ISI
SICI code
0378-1119(1996)178:1-2<191:MOIA-S>2.0.ZU;2-7
Abstract
The pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phage and P1 phage clones from human gen omic DNA and characterized by restriction mapping, Southern blot analy sis, and nucleotide sequencing. The genomic nucleotide sequence, when compared to that of previously determined cDNA sequences, revealed 17 exons encoding the 551-amino-acid PKR protein. We report herein the se quence of the human PKR protein kinase deduced from genomic clones.