N. Nishioka et al., GENE OF RAT CA2+ CALMODULIN-DEPENDENT PROTEIN-KINASE-II ALPHA-ISOFORM- ITS CLONING AND WHOLE STRUCTURE/, FEBS letters, 396(2-3), 1996, pp. 333-336
The gene encoding the ex isoform of rat Ca2+/calmodulin-dependent prot
ein kinase II was cloned, and its exon-intron organization was analyze
d. The coding region of cDNA consists of 18 exons spanning more than 5
0 kilobase pairs, Each of the discrete functional units, such as the A
TP-binding site, the autophosphorylation site responsible for Ca2+-ind
ependent activity, the calmodulin-binding site, and link structure is
encoded by a single exon, The largest and smallest exons consist of 22
9 and 41 base pairs, respectively, All splice junction sequences flank
ing the introns conform to the consensus splice junction sequence and
the GT-AG splice rule.