Vaginourethroplasty was performed in six bitches with infiltrative, ob
structive urethral disease. The initial clinical signs included dysuri
a, hematuria, pollakiuria, and stranguria. Diagnosis was based on the
clinical signs, plain radiography and contrast vagino-urethrogram exam
ination, and urethral biopsy. Five dogs were diagnosed as having ureth
ral neoplasia; the sixth dog had granulomatous urethritis. In all six
dogs, up to 50% of the urethra and the urethral tubercle were resected
to ensure adequate surgical margins. One doe was euthanatized 4 month
s after surgery for recurrence of a transitional cell carcinoma at the
surgical site. Long-term resolution of the problem (minimum of 12 mon
ths) was achieved in the other five dogs. The frequency of serious com
plications, including urinary incontinence and ascending lower urinary
tract infections, was low. (C) Copyright 1996 by The American College
of Veterinary Surgeons