Despite the fact that all the progress in technology, surgical techniq
ue and pathophysiological knowledge has made aortocoronary bypass surg
ery a safe routine procedure, there are certain clinical settings wher
e an alternative approach seems to be advantageous. In 50 patients wit
h age ranging from 51 to 74 years with advanced coronary heart disease
and poor left ventricular (LV) function, as well as in patients with
good LV function and single or double vessel disease not amenable for
PTCA and in patients with acute ischemia or recent myocardial infarcti
on, we performed coronary artery bypass grafting (CABG) without cardio
plegic arrest during a short period of left ventricular unloading by m
eans of a left ventricular assist device (LVAD). During LVAD support w
e administered Esmolol(R) to decrease the heart rate and to keep the h
eart flaccid to facilitate easier peripheral anastomosis on a beating
heart. Preoperative ejection fraction ranged from 15 to 56%.