SMALL PEPTIDE INHIBITORS OF ALPHA(4)BETA(7) MEDIATED MADCAM-1 ADHESION TO LYMPHOCYTES

Authors
SHROFF HN SCHWENDER CF DOTTAVIO D YANG LL BRISKIN MJ
Citation
Hn. Shroff et al., SMALL PEPTIDE INHIBITORS OF ALPHA(4)BETA(7) MEDIATED MADCAM-1 ADHESION TO LYMPHOCYTES, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2495-2500
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
21
Year of publication
1996
Pages
2495 - 2500
Database
ISI
SICI code
0960-894X(1996)6:21<2495:SPIOAM>2.0.ZU;2-E
Abstract
Specificity of leukocyte trafficking to intestinal mucosal tissues is largely mediated by MAdCAM-1/alpha(4) beta(7) interaction. A series of small peptides was prepared to establish L-D-T-S-L as a recognition m otif involved in the alpha(4) beta(7) interaction. N-Terminus acylatio n of the L-D-T-S-L motif has led to low micromolar inhibitors of leuko cyte adhesion. Copyright (C) 1996 Elsevier Science Ltd