Hn. Shroff et al., SMALL PEPTIDE INHIBITORS OF ALPHA(4)BETA(7) MEDIATED MADCAM-1 ADHESION TO LYMPHOCYTES, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2495-2500
Specificity of leukocyte trafficking to intestinal mucosal tissues is
largely mediated by MAdCAM-1/alpha(4) beta(7) interaction. A series of
small peptides was prepared to establish L-D-T-S-L as a recognition m
otif involved in the alpha(4) beta(7) interaction. N-Terminus acylatio
n of the L-D-T-S-L motif has led to low micromolar inhibitors of leuko
cyte adhesion. Copyright (C) 1996 Elsevier Science Ltd