NOVEL SYNTHESIS OF NUCLEOSIDE 5'-POLYPHOSPHATES

Authors
HOFFMANN C GENIESER HG VERON M JASTORFF B
Citation
C. Hoffmann et al., NOVEL SYNTHESIS OF NUCLEOSIDE 5'-POLYPHOSPHATES, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2571-2574
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
21
Year of publication
1996
Pages
2571 - 2574
Database
ISI
SICI code
0960-894X(1996)6:21<2571:NSON5>2.0.ZU;2-6
Abstract
We report a novel synthetic method to prepare nucleoside 5'-di- and tr iphosphates simultaneously. Their preparative separation and the possi bilities to influence the product ratio were investigated. Preliminary results of the triphosphates to act as phosphate donors for the nucle oside diphosphate kinase (EC 2.7.4.6) are presented. Copyright (C) 199 6 Elsevier Science Ltd