PRODUCTION OF (S)-4-CHLORO-3-HYDROXYBUTYRONITRILE USING MICROBIAL RESOLUTION

Authors
SUZUKI T IDOGAKI H KASAI N
Citation
T. Suzuki et al., PRODUCTION OF (S)-4-CHLORO-3-HYDROXYBUTYRONITRILE USING MICROBIAL RESOLUTION, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2581-2584
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
21
Year of publication
1996
Pages
2581 - 2584
Database
ISI
SICI code
0960-894X(1996)6:21<2581:PO(UMR>2.0.ZU;2-0
Abstract
A new production procedure of (S)-4-chloro-3-hydroxybutyronitrile was developed using microbial resolution. The resting cells of Pseudomonas sp. OS-K-29 preferentially converted (R)-4-chloro-3-hydroxybutyronitr ile to the corresponding 1,2-diol by the dehalogenating activity so th at (S)-4-chloro-3-hydroxybutyronitrile (94.5 %ee) was obtained from th e racemate in 40% yield at the microbial resolution step. Copyright (C ) 1996 Elsevier Science Ltd