GLUTATHIONE POTENTIATES CGMP SYNTHESIS INDUCED BY THE 2 PHENYLFUROXANCARBONITRILE ISOMERS IN RFL-6 CELLS

Authors
DISTILO A CENA C GASCO AM GASCO A GHIGO D BOSIA A
Citation
A. Distilo et al., GLUTATHIONE POTENTIATES CGMP SYNTHESIS INDUCED BY THE 2 PHENYLFUROXANCARBONITRILE ISOMERS IN RFL-6 CELLS, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2607-2612
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
21
Year of publication
1996
Pages
2607 - 2612
Database
ISI
SICI code
0960-894X(1996)6:21<2607:GPCSIB>2.0.ZU;2-V
Abstract
The cellular mechanism of bioactivation underlying guanylate cyclase a ctivation by the pair of phenylfuroxancarbonitrile isomers 2a, b was i nvestigated. In cultured rat lung fibroblast (RFL-6 cells) it was prin cipally dependent on intracellular thiols. Copyright (C) 1996 Elsevier Science Ltd