SPINOCEREBELLAR MOSSY FIBER TERMINAL TOPOGRAPHY IN THE NR2C PKC-GAMMADOUBLE MUTANT CEREBELLUM/

The spatiotemporal expression patterns of the NR2C subunit of the NMDA receptor and PKC gamma isoform during cerebellar development suggests that both proteins are involved in the molecular mechanisms of synapt ogenesis, However, the topographic distribution of WGA-HRP labeled spi nocerebellar messy fiber terminals in NR2C/PKC gamma double mutants (n = 4) appears similar to controls (n = 3). While the results do not ru le out a role for NR2C receptor subunits acid the PKC gamma isoform in cerebellar synaptogenesis, they indicate that neither is necessary fo r the formation or maintenance of normal spinocerebellar messy fiber a fferent maps.