POSTNATAL-DEVELOPMENT OF PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS IN RAT-BRAIN AND PERIPHERAL-TISSUES

We examined the postnatal development of peripheral-type benzodiazepin e receptors (PBRs), labelled with [H-3]PK 11195, in rat brain and peri pheral tissues. Specific [H-3]PK 11195 binding exhibited a heterogeneo us patterns of postnatal development in the rat: three patterns of inc rease, decrease and no change. Hence, the density of the PBRs can be i ndependently regulated in each tissue during postnatal development, an d the postnatal alterations in the density might be parallel with the functional activities coupled to the receptors.