ENOXIMONE USAGE FOR EXPERIMENTAL SPINAL-CORD PROTECTION DURING AORTICCROSS-CLAMPING

Spinal cord preservation during aortic cross-clamping is of vital impo rtance. Maintenance of spinal cord blood supply is one of the key poin ts for spinal cord preservation. In this study enoximone was selected as an agent to reduce the risk of spinal cord injury because of its in otropic and vasodilator actions. Ten dogs underwent sixty minutes aort ic occlusion. Five animals received enoximone and the others did not ( the control group). Enoximone dosage was 10 microgram/kg/min. Four dog s in the control group suffered paraplegia. There were no paraplegic e vents in the enoximone group. Cerebrospinal fluid pressure was 17 +/- 3 mmHg in the control group, 15 +/- 4 mmHg in the enoximone group. Dis tal aortic pressure was 15 +/- 4 mmHg in the control group, 47 +/- 6 i n the enoximone group (p < 0.001). In this study we conclude that enox imone is an effective agent to reduce the risk of spinal cord injury.