DAY NIGHT RATIO OF MICROPROTEINURIA AND BLOOD-PRESSURE RHYTHM IN TYPE-II DIABETES/

The paper discusses the results of the studies conducted with a group of patients with type II diabetes without clinical nephropathy. The ai m of the study was to attempt to determine the markers for early stage s of diabetic nephropaty in NIDDM patients. The following examinations were carried out: the level of selected microproteinuric components, 24 h monitoring of arterial blood pressure, and electrocardiogram (ECG ). Among the patients examined, the level of alfa-1-microglobulin, alb umin and immunoglobulin G (IgG) in diabetic patients was higher than i n the control group, and the increased activity of beta NAG was observ ed. The 24 h profile of blood pressure and the ratio afternoon/night o f albumin excretion flattened in the majority of diabetic patients. Th e results of the study suggest that the proximal tubules and the membr anes of renal glomeruli are damaged as early as during the period of s ubclinical diabetic nephropathy.