The water rat, Nectomys squamipes, is reported as a natural host of Sc
histosoma mansoni in Brazil. This paper presents some reproductive, gr
owth and developmental data, and laboratory management of a breeding p
rogramme for N. squamipes. The colony was derived from animals capture
d at Sumidouro, Rio de Janeiro state. The animals' diploid number was
56, conception rate was 66.7% and gestation period was 30 days. Litter
size ranged from 1 to 6, with a mean of 4.1 (SD +/- 1.2) and a mode o
f 4 and 5. Sex ratio at birth and at weaning was not significantly dif
ferent from the expected ratio of 1:1. There were no significant diffe
rences between mean body weights at birth for males and females. The m
inimum age for weaning was between 20-25 days. The growth curves of bo
dy weight, head-body length and tail length, for both sexes, comprise
at least three linear segments representing different phases of approx
imately constant growth rates. Facilities for colony maintenance and i
ts potential for use as experimental model are reported.