ROLE OF THYROID-HORMONES IN REGULATION OF PHOSPHATIDIC-ACID, PHOSPHATIDYLINOSITOL, AND POLYPHOSPHOINOSITIDE SYNTHESIS IN LIVER-CELLS

Authors
KRASILNIKOVA OA BABENKO NA
Citation
Oa. Krasilnikova et Na. Babenko, ROLE OF THYROID-HORMONES IN REGULATION OF PHOSPHATIDIC-ACID, PHOSPHATIDYLINOSITOL, AND POLYPHOSPHOINOSITIDE SYNTHESIS IN LIVER-CELLS, Biochemistry, 61(8), 1996, pp. 1008-1014
Citations number
24
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
61
Issue
8
Year of publication
1996
Pages
1008 - 1014
Database
ISI
SICI code
0006-2979(1996)61:8<1008:ROTIRO>2.0.ZU;2-V
Abstract
The influence of thyroxine on synthesis of total phospholipids, phosph atidic acid, phosphatidylinositol, phosphatidylinositol-3-phosphate, a nd phosphatidylinositol-3,5-bisphosphate was investigated in hepatocyt es of white rats. The hormone induced a manyfold increase in [C-14]pal mitate incorporation into the investigated lipids. The activating effe ct of the hormone on lipid synthesis is imitated by phorbol 12-myrista te 13-acetate and abolished by exogenous sphingosine. Addition of sphi ngosine to intact cells inhibits phosphoinositide synthesis.