Because most radiologists in the United States have been taught that f
luoroscopy and computed tomography (CT) are the best guidance techniqu
es for nonvascular interventional procedures, sonography has been grea
tly underused in this regard. Recently, sonography has been gaining re
cognition as a highly useful and versatile guidance technique. It has
many advantages over CT and fluoroscopic guidance, including real-time
imaging with vessel visualization, decreased procedure time and cost,
portability, and lack of ionizing radiation. Sonography should be the
primary guidance technique for many nonvascular interventional proced
ures, and use of sonography as an adjunct guidance technique increases
the ease and speed with which many other interventional procedures ar
e performed. Sonography should generally be used instead of CT for gui
dance of abdominal and pelvic biopsy and drainage. Sonographic guidanc
e should replace CT and fluoroscopic guidance for biopsy and drainage
of accessible peripheral thoracic and mediastinal masses. Use of sonog
raphic guidance should be integrated into all interventional radiology
suites to reduce radiation exposure and facilitate the performance of
many nonvascular and some vascular interventional procedures that hav
e traditionally been performed under fluoroscopic guidance.