Reduction of pain without systematic side effects can be achieved in a
dvanced stages of cancer with precise percutaneous techniques guided w
ith computed tomography (CT), CT guidance allows exact needle position
ing, reducing complications and improving the results, Regional analge
sia with neurolytic block (neurolysis) is achieved by injection of alc
ohol or phenol and involves intentional destruction of a nerve or nerv
es to interrupt nociceptive pathways for weeks or months, Percutaneous
alcoholization of bone metastasis is indicated in patients with painf
ul, severe, osteolytic bone metastasis if conventional anticancer ther
apy is ineffective and high doses of opiates are necessary to control
pain and when rapid pain relief is necessary. Bone packing with acryli
c glue (methyl methacrylate) is used to prevent pathologic fractures a
nd pain in patients with vertebral body tumors and acetabular metastas
is, With these techniques, the radiologist is able to play an active r
ole in pain management and in improving the quality of life of patient
s with malignancies.