PREVALENCE OF ARTERIAL-HYPERTENSION AND I SCHEMIC-HEART-DISEASE IN DIFFERENT TYPES OF DYSLIPOPROTEINEMIA AMONG MEN AGED 20-59 YEARS IN MOSCOW

Prevalence of arterial hypertension and ischemic heart disease in pers ons with dyslipidemias and ''normal'' lipids was studied in a represen tative sample of Moscow male population aged 20-59 years. Standard epi demiological techniques were used for diagnosis of ischemic heart dise ase. Of total number of 3201 men 24,55% had hypertension (systolic blo od pressure higher than 160 mm Hg and/or diastolic blood pressure abov e 95 mm Hg). Prevalence of different variants of disturbances of lipid metabolism was 54,5% in 741 males with hypertension and 41% in men wi th normal blood pressure. Portion of men with hypertension varied from 24,6% in men with hypoalphacholesterolemia to 41% in men with type II B hyperlipoproteinemia combined with hypoalphacholesterolemia. Among 4 03 men with hypertension and hyperlipoproteinemia 78,2% had hypoalphac holesterolemia and type IIA hyperlipoproteinemia. Ischemic heart disea se was twice more frequent in men with elevated blood pressure compare d to men with normal blood pressure. Portion of patients with ischemic heart disease and disturbances of lipid metabolism among men with hyp ertension was higher than among persons with normal blood pressure (67 ,88 and 54,75%, respectively). Among men with ischemic heart disease w ith normal and elevated blood pressure portions of persons with concom itant hypoalphacholesterolemia and type IIA hyperlipoproteinemia were comparable while portion of persons with ischemic heart disease in men with arterial hypertension was 1,8 times higher in type IIB hyperlipo proteinemia and 2,4 times higher in type IV hyperlipoproteinemia. A sp ecial questionnaire was used for assessment of family history of cardi ovascular diseases. In men whose parents had cardiovascular diseases p revalence of hypertension was significantly higher among persons with dyslipidemia than among those with normal lipids (20,2% and 12,5% resp ectively, p<0,05). In the whole sample of male population there were 1 954 men (64,7%) with family history of cardiovascular diseases. The da ta presented support the idea that dyslipoproteinemia and hypertension in some cases were manifestations of a common hereditary syndrome.