EXCRETION OF ORAL 9-CIS-RETINOIC ACID IN THE RAT

Authors
DISDIER B BUN H PLACIDI M DURAND A
Citation
B. Disdier et al., EXCRETION OF ORAL 9-CIS-RETINOIC ACID IN THE RAT, Drug metabolism and disposition, 24(11), 1996, pp. 1279-1281
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug metabolism and disposition → ACNP
ISSN journal
00909556
Volume
24
Issue
11
Year of publication
1996
Pages
1279 - 1281
Database
ISI
SICI code
0090-9556(1996)24:11<1279:EOO9AI>2.0.ZU;2-T
Abstract
We have studied excretion of oral O-cis-retinoic acid in urine and fec es in vigil rats and in bile in anesthetized rats, A proportion of 53 +/- 13% of the dose of 9-cis-retinoic acid administered was eliminated through the feces in 72 hr, and the urinary excretion was negligible. The prevalent form of elimination in feces and urine was the unchange d compound. Low biliary excretion was, for the most part, composed of metabolites.