3 IODINATION METHODS FOR LABELING RADIOPHARMACEUTICALS

Three methods are used for iodination of radiopharmaceuticals in a hos pital. The Chloramine-T method, which is the oldest, is cheap and conv enient; it has been used for twenty years. Solid-phase methods were de veloped for radioiodination of small peptides and proteins. The most p opular solid-phase method is the Iodogen-TM method. Several bioactive proteins were iodinated by this method. Lactoperoxidase method was use d for enzymatic iodination in the solid and liquid phases. Solid-phase lactoperoxidase method was developed for those peptides and proteins that are labile at pH 7 and higher.