PROGNOSTIC-SIGNIFICANCE OF IMMUNOHISTOCHEMICALLY DETECTED P53 PROTEINEXPRESSION IN STAGE IIIB SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX TREATED WITH RADIATION-THERAPY ALONE
T. Ebara et al., PROGNOSTIC-SIGNIFICANCE OF IMMUNOHISTOCHEMICALLY DETECTED P53 PROTEINEXPRESSION IN STAGE IIIB SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX TREATED WITH RADIATION-THERAPY ALONE, Gynecologic oncology, 63(2), 1996, pp. 216-218
Immunohistochemical studies were performed to investigate the prognost
ic significance of p53 protein expression in 46 patients with stage II
IB squamous cell carcinoma of the uterine cervix who were treated with
radiation therapy alone. Tumor cells showed p53 protein expression in
29 of 46 patients, The 5-year overall actuarial and cause-specific su
rvival rates for the patients with p53-positive tumor were 52.9 and 70
.4%, respectively. The corresponding rates for the patients with p53-n
egative tumor were 58.2 and 69.0%, respectively. There was no signific
ant difference of local control rates and of distant metastases rates
between the two groups, In conclusion, no relationship was observed be
tween radiation treatment outcome and the immunohistochemically detect
ed p53 protein expression in the patients with stage IIIB squamous cel
l carcinoma of the uterine cervix. (C) 1996 Academic Press, Inc.