PROGNOSTIC-SIGNIFICANCE OF IMMUNOHISTOCHEMICALLY DETECTED P53 PROTEINEXPRESSION IN STAGE IIIB SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX TREATED WITH RADIATION-THERAPY ALONE

Citation
T. Ebara et al., PROGNOSTIC-SIGNIFICANCE OF IMMUNOHISTOCHEMICALLY DETECTED P53 PROTEINEXPRESSION IN STAGE IIIB SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX TREATED WITH RADIATION-THERAPY ALONE, Gynecologic oncology, 63(2), 1996, pp. 216-218
Citations number
20
Categorie Soggetti
Oncology,"Obsetric & Gynecology
Journal title
ISSN journal
00908258
Volume
63
Issue
2
Year of publication
1996
Pages
216 - 218
Database
ISI
SICI code
0090-8258(1996)63:2<216:POIDPP>2.0.ZU;2-Y
Abstract
Immunohistochemical studies were performed to investigate the prognost ic significance of p53 protein expression in 46 patients with stage II IB squamous cell carcinoma of the uterine cervix who were treated with radiation therapy alone. Tumor cells showed p53 protein expression in 29 of 46 patients, The 5-year overall actuarial and cause-specific su rvival rates for the patients with p53-positive tumor were 52.9 and 70 .4%, respectively. The corresponding rates for the patients with p53-n egative tumor were 58.2 and 69.0%, respectively. There was no signific ant difference of local control rates and of distant metastases rates between the two groups, In conclusion, no relationship was observed be tween radiation treatment outcome and the immunohistochemically detect ed p53 protein expression in the patients with stage IIIB squamous cel l carcinoma of the uterine cervix. (C) 1996 Academic Press, Inc.