SPONTANEOUS HEMOPERITONEUM FROM BRODIFACOUM OVERDOSE

Brodifacoum is a 4-hydroxycoumarin derivative that is commonly used as a rodenticide, Human exposures have produced severe coagulopathies re sulting in hematuria, gastrointestinal bleeding, intracranial hemorrha ge, and death. This is the first report of spontaneous hemoperitoneum secondary to brodifacoum ingestion, The patient was successfully manag ed with fresh frozen plasma, packed red blood cells, and vitamin K-1. No surgical intervention was performed. The patient required ongoing d aily vitamin K-1 therapy for longer than 6 months. Copyright (C) 1996 by W.B. Saunders Company