Pck. Cheung, THE HYPOCHOLESTEROLEMIC EFFECT OF EXTRACELLULAR POLYSACCHARIDE FROM THE SUBMERGED FERMENTATION OF MUSHROOM, Nutrition research, 16(11-12), 1996, pp. 1953-1957
Male Sprague-Dawley rats were fed two semisynthetic diets supplemented
with 2% cholesterol, and 1% beta-glucan type extracellular polysaccha
ride isolated from two liquid cultures of straw mushroom (Volvariella
volvacea) mycelium containing different carbon sources. The experiment
al diets containing the two mycelial extracellular polysaccharides had
induced a significant reduction in the levels of serum total choleste
rol, LDL-cholesterol, and liver total cholesterol in the animals. Ther
e was no significant changes in the concentrations of serum triacylgly
cerol, HDL-cholesterol and liver total lipids. The fecal neutral stero
id level was significantly increased while the fecal bile acid excreti
on was not significantly affected. Both mycelail extracellular polysac
charides exhibited hypocholesterolemic activity in rats with alimentar
y-induced hypercholesterolemia. Copyright (C) 1996 Elsevier Science In
c.