SYNTHETIC STUDY ON CURACIN-A - A NOVEL ANTIMITOTIC AGENT FROM THE CYANOBACTERIUM LYNGBYA-MAJUSCULA

Authors
ONODA T SHIRAI R KOISO Y IWASAKI S
Citation
T. Onoda et al., SYNTHETIC STUDY ON CURACIN-A - A NOVEL ANTIMITOTIC AGENT FROM THE CYANOBACTERIUM LYNGBYA-MAJUSCULA, Tetrahedron, 52(46), 1996, pp. 14543-14562
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
46
Year of publication
1996
Pages
14543 - 14562
Database
ISI
SICI code
0040-4020(1996)52:46<14543:SSOC-A>2.0.ZU;2-Z
Abstract
Curacin A (1), a novel antimitotic agent, was synthesized in a highly stereo-controlled manner. The four stereoisomers of a partial structur e at the thiazoline moiety, 2 were also synthesized to aid in elucidat ion of the absolute configurations of three chiral centers in curacin A. The effects on porcine brain tubulin assembly of several synthetic compounds related to curacin A were examined. Copyright (C) 1996 Elsev ier Science Ltd