INTERCONVERTIBLE (Z E)-STEREOISOMERS OF A VITAMIN-B-6 COENZYME ANALOGDERIVED FROM PYRIDOXAL 5'-PHOSPHATE AND RHODANINE/

Authors
KESEL AJ URBAN S OBERTHUR W
Citation
Aj. Kesel et al., INTERCONVERTIBLE (Z E)-STEREOISOMERS OF A VITAMIN-B-6 COENZYME ANALOGDERIVED FROM PYRIDOXAL 5'-PHOSPHATE AND RHODANINE/, Tetrahedron, 52(47), 1996, pp. 14787-14800
Citations number
46
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
47
Year of publication
1996
Pages
14787 - 14800
Database
ISI
SICI code
0040-4020(1996)52:47<14787:I(EOAV>2.0.ZU;2-D
Abstract
The Knoevenagel condensation product of pyridoxal 5'-phosphate (1) wit h rhodanine (2) was prepared and identified as oxy-2-methyl-5-[(phosph onooxy)methyl]-4-pyridinyl] methylene]-2-thioxo-4-thiazolidinone (3). The labile (E)-stereoisomer 4 was obtained in a crude form. Its associ ation with the nucleobase adenine was prepared suggesting an affinity to nucleic acids. Copyright (C) 1996 Elsevier Science Ltd