ANTIPSYCHOTIC DRUG EFFECTS IN A MODEL OF SCHIZOPHRENIC ATTENTIONAL DISORDER - A RANDOMIZED CONTROLLED TRIAL OF THE EFFECTS OF HALOPERIDOL ON LATENT INHIBITION IN HEALTHY PEOPLE

We studied the effects of haloperidol (0.5 mg, intravenously) on laten t inhibition in an auditory paradigm and two visual paradigms in healt hy subjects, Haloperidol increased latent inhibition in one visual par adigm and tended to increase latent inhibition in an auditory task, co mpared to saline-injected controls. These results indicate that halope ridol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent in hibition. (C) 1996 Society of Biological Psychiatry