BACLOFEN PRETREATMENT ATTENUATES THE SUPPRESSANT EFFECT OF INTRAPERITONEAL ADMINISTRATION OF CHOLECYSTOKININ (CCK) ON FOOD-INTAKE IN RATS

The aim of this study was to investigate whether pretreatment with the GABAB receptor agonist baclofen could prevent the inhibitory effect o f systemically administered cholecystokinin (CCK) on food intake in ra ts, Baclofen (2 mg/kg, SC) administered 60 min prior to IP injection o f CCK (5 mu g/kg) significantly attenuated the suppressant effect of t he peptide on feeding in nondeprived rats (Experiment 1) and rats that had been deprived of food for 22 h (Experiment 2). Baclofen had no si gnificant effects on food intake when administered alone, The results suggest that the inhibitory effect of exogenous peripheral CCK on food intake may be dependent on an interaction with a GABAB-receptor media ted mechanism. Copyright (C) 1996 Elsevier Science Inc.