IN-VITRO BIOSYNTHETIC-STUDIES OF THE BRYOSTATINS, ANTICANCER AGENTS FROM THE MARINE BRYOZOAN BUGULA-NERITINA

Authors
KERR RG LAWRY J GUSH KA
Citation
Rg. Kerr et al., IN-VITRO BIOSYNTHETIC-STUDIES OF THE BRYOSTATINS, ANTICANCER AGENTS FROM THE MARINE BRYOZOAN BUGULA-NERITINA, Tetrahedron letters, 37(46), 1996, pp. 8305-8308
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
46
Year of publication
1996
Pages
8305 - 8308
Database
ISI
SICI code
0040-4039(1996)37:46<8305:IBOTBA>2.0.ZU;2-Y
Abstract
Acetate, S- adenosylmethionine and glycerol have been identified as ke y building blocks of the anticancer polyketide, bryostatin 1, through a series of in vitro biosynthetic experiments. The active enzyme prepa ration was fortified with ATP, Mg2+, NADH and NADPH. Copyright (C) 199 6 Elsevier Science Ltd