OXIDIZING MECHANISM OF PODOPHYLLOTOXIN AND ITS DERIVATIVES BY SODIUM PERSULFATE

Authors
WANG SL YAO SD ZHANG ZC ZHANG MW JIANG Y
Citation
Sl. Wang et al., OXIDIZING MECHANISM OF PODOPHYLLOTOXIN AND ITS DERIVATIVES BY SODIUM PERSULFATE, Science in China. Series B, Chemistry, life sciences & earth sciences, 39(4), 1996, pp. 425-432
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Science in China. Series B, Chemistry, life sciences & earth sciences → ACNP
ISSN journal
1001652X
Volume
39
Issue
4
Year of publication
1996
Pages
425 - 432
Database
ISI
SICI code
1001-652X(1996)39:4<425:OMOPAI>2.0.ZU;2-O
Abstract
The oxidizing mechanism of podophyllotoxin and its derivatives by sodi um persulfate has been studied by laser flash photolysis and pulse rad iolysis. The formation and decay processes of transient species of pod ophyllotoxin and its derivatives have been observed, and a series of r ate constants for the formation and decay of transient species have be en determined. It has been found that there is a light (UV) sensitive group on the C-4 of podophyllotoxin and two light (UV) sensitive group s on the C-4 and C-4' of 4'-demethylepipodophyllotoxin.