DELIVERY AFTER BONE-MARROW TRANSPLANTATION WITH TOTAL LYMPHOID IRRADIATION FOR SEVERE APLASTIC-ANEMIA

A 28-year old woman delivered a normal child at 85 months after bone m arrow transplantation (BMT) for severe aplastic anemia (SAA). BMT was done after conditioning with cyclophosphamide (CY: 50 mg/kg/day for 4 days), anti-lymphocyte globulin (ALG: 50 mg/kg/day for 3 days) and tot al lymphoid irradiation (TLI: 5 Gy in a single fraction). Ovarian shie lding was not done during irradiation. Six months after BMT, she gaine d normal menstruation spontaneously. Serum gonadotrophin levels were w ithin the normal range, with an LH level of 34.6 mIU/ml (normal. 1-36 mIU/ml) and an FSH level of 13.4 mIU/ml (normal: 1-30 mIU/ml), at 38 m onths after BMT. She became pregnant 8 years after BMT and delivered a female child, who is now 3 years old and shows normal development.