MICELLAR ELECTROKINETIC CHROMATOGRAPHY OF CEPHALOSPORIN ANTIBIOTICS

A simple micellar electrokinetic chromatographic (MEKC) method is desc ribed for the simultaneous separation of twelve cephalosporin antibiot ics. The separation was performed in a phosphate buffer (0.1 M, pH 6.6 ) with sodium dodecyl sulfate (SDS) (0.1 M) as an anionic surfactant. The complete separation of twelve cephalosporins was attained in 36 mi n. Application of the method to the quantitative analysis of cefuroxim e, cephalexin, cephapirin and cephradine in pharmaceutical preparation s was demonstrated.