Bk. Hwang et al., ISOLATION, STRUCTURE ELUCIDATION, AND ANTIFUNGAL ACTIVITY OF A MANUMYCIN-TYPE ANTIBIOTIC FROM STREPTOMYCES-FLAVEUS, Journal of agricultural and food chemistry, 44(11), 1996, pp. 3653-3657
A manumycin-type antibiotic, SW-B, has been isolated from the solid ag
ar culture of Streptomyces flaveus strain A-11. The structure was dete
rmined by mass spectrometry and one- and two-dimensional NMR spectrosc
opy. SW-B was detected at R(f) 0.5 on the TLC plate developed with chl
oroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol show
ed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a
derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)
-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activit
y against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucum
erinum, and Alternaria mall. However, it lacked antimicrobial activity
against yeast and bacteria.