A three-year-old girl who underwent an operation for adrenal neuroblas
toma was anaesthetized with sevoflurane and epidural analgesia. In the
immediate recovery period she had convulsions. The convulsions were s
uccessfully treated with thiopentone and sevoflurane, there were no ne
urological sequelae. The convulsions were considered to be a manifesta
tion of mepivacaine toxicity because of a high plasma mepivacaine conc
entration. Complications of paediatric regional analgesia and manifest
ations of mepivacaine toxicity under sevoflurane anaesthesia are discu
ssed.