EFFECTS OF SODIUM OZAGREL ON HEMOSTATIC MARKERS AND CEREBRAL BLOOD-FLOW IN LACUNAR INFARCTION

The present study was designed to examine the effects of sodium ozagre l on hemostatic markers and cerebral blood flow in lacunar infarction. Ten cases of lacunar infarction in which sodium ozagrel was given (ad ministered group), 10 cases of lacunar infarction in which sodium ozag rel was not given (nonadministered group), and 10 age-matched controls in which cerebrovascular diseases were absent but risk factors were s imilar to those of the patients (control group) were studied. Intraven ous infusion of SO mg of sodium ozagrel was done twice a day for 2 wee ks, Platelet factor 4, beta-thromboglobulin, and fibrinopeptide A were significantly higher in the administered and nonadministered groups t han in the control group at the lime of admission. Platelet factor 4, beta-thromboglobulin, fibrinopeptide A, and thromboxane B-2 were decre ased significantly by the administration of sodium ozagrel. The blood flow in the cerebral cortex was significantly lower in the administere d and nonadministered groups than in the control group, The blood flow s around the infarcted area, in the cerebral cortex, and in the cerebr al white matter were significantly increased by the administration of sodium ozagrel. Sodium ozagrel is considered to decrease platelet aggr egation and increase cerebral blood flow by decreasing thromboxane A(2 ), which has a platelet-aggregating and a vasoconstricting action, Sod ium ozagrel is considered to be effective in the acute phase of lacuna r infarction.