Many infectious disease threats to U.S. military operations are uncomm
on in the United States, The advanced development and testing of count
ermeasures, such as vaccines, drugs, or insect repellents, requires th
e capability to study militarily important infectious diseases where t
hey occur. With formal agreements between the U.S. and each host count
ry, the U.S. military operates seven overseas medical research laborat
ories (labs), Six labs conduct infectious disease research and are dis
tributed over three continents; Africa (labs in Egypt and Kenya), Asia
(labs in Indonesia and Thailand), and South America (labs in Brazil a
nd Peru), One other lab is located in Germany and conducts psychosocia
l research related to military personnel and their families. In additi
on to product development, these labs play vital roles supporting over
seas deployments, providing technical training, and promoting internat
ional relations, Also, these labs are well positioned to become part o
f a developing global surveillance and response system to help address
the threat posed by emerging infectious diseases, This article will p
resent an overview of this unique medical research capability, describ
e the history and some of the activities of each lab, and discuss the
importance of maintaining these labs in the 21st century.