HEPATIC ANGIOSARCOMA IN A CHILD - SUCCESSFUL THERAPY WITH SURGERY ANDADJUVANT CHEMOTHERAPY

We report a 3-year and 11-month-old Caucasian female, who initially pr esented with an unresectable hepatic angiosarcoma. After three courses of chemotherapy with adriamycin/cisplatin, the tumor decreased in siz e considerably, allowing complete surgical resection. She also receive d postoperative chemotherapy with alternating cycles of ifosfamide/eto poside, cisplatinum/adriamycin, and vincristine/actinomycin D/cyclopho sphamide for 18 months. She remains disease-free for greater than 44 m onths from the initial diagnosis. Our experience suggests that total e xcision of the tumor, together with an aggressive chemotherapy regimen , can improve the disease-free survival for children with this highly malignant vascular tumor of the liver. (C) 1997 Wiley-Liss, Inc.