Nm. Sanderson et Mn. Jones, ENCAPSULATION OF VANCOMYCIN AND GENTAMICIN WITHIN CATIONIC LIPOSOMES FOR INHIBITION OF GROWTH OF STAPHYLOCOCCUS-EPIDERMIDIS, Journal of drug targeting., 4(3), 1996, pp. 181-189
Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC
), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB).
The cationic vesicles adsorb to biofilms of the skin-associated bacter
ia Staphylococcus epidermidis, which have a negative charge. Encapsula
tion of the antibacterial drug vancomycin into such liposomes enhanced
its activity relative to the free agent. The effectiveness of the pre
paration was dependent on the fluidity of the liposomal membrane and o
n the level of drug entrapment within the aqueous core of the vesicles
. The aminoglycoside antibiotic gentamicin was also encapsulated withi
n similar liposomes but was less effective, possibly due to its slow p
assage through the membrane. The Liposomal vancomycin preparation has
potential medical use in treating bacterial infections of foreign body
biomedical devices (e.g. catheters), with either topical or intraveno
us administration.