MONO-AROYLATION OF 2,3-DIAMINOPYRIDINE AND 3,4-DIAMINOPYRIDINE AND 4,5-DIAMINOPYRIMIDINE, AND SYNTHESES OF PUTATIVE INOTROPE BETA-ADRENOCEPTOR ANTAGONISTS/

Authors
BARRACLOUGH P COLLARD D GILLAM J KING WR SMITH S
Citation
P. Barraclough et al., MONO-AROYLATION OF 2,3-DIAMINOPYRIDINE AND 3,4-DIAMINOPYRIDINE AND 4,5-DIAMINOPYRIMIDINE, AND SYNTHESES OF PUTATIVE INOTROPE BETA-ADRENOCEPTOR ANTAGONISTS/, Journal of chemical research. Synopses, (9), 1996, pp. 406-407
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
9
Year of publication
1996
Pages
406 - 407
Database
ISI
SICI code
0308-2342(1996):9<406:MO2A3A>2.0.ZU;2-Z
Abstract
Mono-aroylation with the oxazolidinone benzoyl chloride (4) and tert-b utoxylation with Boc(2)O occurs at N-3 of 2,3-diaminopyridine, N-4 of 3.4-diaminopyridine and N-4 (or N-5) of 4,5-diaminopyrimidine; the mon oamides 6, 8 and 10 thus obtained from 4 were converted to putative in otropic/beta-adenoceptor antagonists 1-3.