MUTAGENICITY OF SYNTHETIC ACRIDINONES AND THIOACRIDINES IN DIRECT AMES SALMONELLA MUTAGENICITY ASSAY

Newly synthesized antitrypanosomal and antiplasmid acridinones, thio-s ubstituted acridines and thioacridinones were tested for a direct geno toxic effect on TA97a and TA100 tester strains by times' Salmonella mu tagenicity assay. Of acridinones, only 9-(hydrazinothiazolo[5,4-a])acr idinone 1 showed strong mutagenic activity on TA97a strain. However, m utagenic activity was manifested invariably by all three acridinones o n TA100 strain. Of thioacridines, 2,7-dimethoxy-9-thioacridinone 4, 2, 7-dimethoxy-9-(3'-aminopropyl) 5 and 2,7-dihydroxy-9-acetamidothioacri dine 6 were explicitly mutagenic on TA97a, but on TA100 they were just weakly mutagenic.