To estimate the impact of the exposure to spermatozoa on the risk of d
eveloping pregnancy-induced hypertension, the duration of sexual cohab
itation with the father and the use of contraceptive methods were eval
uated among 113 primigravid women with pregnancy-induced hypertension
and 109 age- and parity-matched controls, The duration of unprotected
sexual cohabitation was similar to 50% shorter in women with pregnancy
-induced hypertension (2.3 versus 4.7, P < 0.0001), regardless of the
contraceptive method previously used. However the duration of oral con
traception use was similar in cases and controls (22.1 versus 23.4 mon
ths), Also, of the total group of women who developed pregnancy-induce
d hypertension, 85.8% (97) became pregnant during the first 3 months o
f unprotected sexual intercourse in comparison with 54.1% (59) in the.
control group (P < 0.0001). Results suggest that the risk of pregnanc
y-induced hypertension in primigravidae is reduced with duration of se
xual cohabitation, and therefore with exposure to paternal spermatozoa
. However the protective effect of exposure is not achieved while usin
g oral contraceptives, Considering the present options for nulliparous
women, contraception does not appear to be a viable public health pol
icy to reduce the risk of pregnancy-induced hypertension.