A. Carpi et al., ASPIRATION NEEDLE-BIOPSY REFINES PREOPERATIVE DIAGNOSIS OF THYROID-NODULES DEFINED AT FINE-NEEDLE ASPIRATION AS MICROFOLLICULAR NODULE, Biomedicine & pharmacotherapy, 50(8), 1996, pp. 325-328
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
The aim of this paper was to verify the hypothesis that large needle b
iopsy performed preoperatively can refine preoperative fine needle asp
iration (FNA) cytological diagnoses of microfollicular nodules. Since
1980 we have been using FNA and aspiration needle biopsy (ANB) (18 or
16 gauge needles) to select for surgery all euthyroid patients with pa
lpable thyroid nodules referred to our department. From 1980 to 1994,
6,124 patients (12% male, 88% female) with thyroid nodules (71% single
, 29% multiple) were examined by FNA; 29% of these patients were also
examined preoperatively by ANB histology. Of all the nodule patients e
xamined, 371 received a preoperative FNA diagnosis of microfollicular
nodule. Two hundred and fifty-four of these nodules (68%) were also ex
amined preoperatively by ANB. Unsatisfactory ANB specimens constituted
17% of cases; pure microfollicular structure was confirmed by ANB in
36% of the nodules; ANB showed the remaining 47% to contain a macrofol
licular component, thus suggesting a benign hyperplastic lesion. Twelv
e nodules which were found to be microfollicular at FNA cytology and m
icro-macrofollicular at ANB were excised and were subsequently determi
ned as benign at definitive postoperative histology. These data indica
te the utility of ANB in refining the preoperative FNA diagnosis of mi
crofollicular nodule and in preoperatively identifying benign hyperpla
stic mixed micro-macrofollicular lesions which can be followed by obse
rvation.