FIXATION OF PHARMACOLOGICALLY ACTIVE AMINES ON POLYPHOSPHONATES .3. SYNTHESIS AND PRELIMINARY IN-VITRO CYTOTOXIC STUDIES OF BIS(2-CHLOROETHYL)AMINO GROUP CONTAINING POLYPHOSPHONATES

Authors
FONTAINE L MARBOEUF C BROSSE JC MAINGAULT M DEHAUT F
Citation
L. Fontaine et al., FIXATION OF PHARMACOLOGICALLY ACTIVE AMINES ON POLYPHOSPHONATES .3. SYNTHESIS AND PRELIMINARY IN-VITRO CYTOTOXIC STUDIES OF BIS(2-CHLOROETHYL)AMINO GROUP CONTAINING POLYPHOSPHONATES, Macromolecular chemistry and physics, 197(11), 1996, pp. 3613-3621
Citations number
26
Categorie Soggetti
Polymer Sciences
Journal title
Macromolecular chemistry and physics → ACNP
ISSN journal
10221352
Volume
197
Issue
11
Year of publication
1996
Pages
3613 - 3621
Database
ISI
SICI code
1022-1352(1996)197:11<3613:FOPAAO>2.0.ZU;2-0
Abstract
Hydrosoluble poly(3,6,9-trioxaundecamethylene phosphonate) with attach ed cytotoxic bis(2-chloroethyl)amine in the side chain was synthesized by chemical modification of the corresponding polyphosphonate via the Atherton-Todd reaction. The structure of the product was confirmed by H-1, C-13 and P-31 NMR spectroscopy. Preliminary in vitro cytotoxic s tudies revealed that the polymeric derivative exhibited an eight fold more cytotoxic potency against human hepatocellular carcinoma cell lin e HepG2 than against murine leukemia cell line L1210.