ANTIMUTAGENICITY OF EUGENOL IN THE RODENT BONE-MARROW MICRONUCLEUS TEST

Authors
ROMPELBERG CJM STENHUIS WH DEVOGEL N VANOSENBRUGGEN WA SCHOUTEN A VERHAGEN H
Citation
Cjm. Rompelberg et al., ANTIMUTAGENICITY OF EUGENOL IN THE RODENT BONE-MARROW MICRONUCLEUS TEST, Mutation research. Mutation research letters, 346(2), 1995, pp. 69-75
Citations number
27
Journal title
Mutation research. Mutation research letters → ACNP
ISSN journal
01657992
Volume
346
Issue
2
Year of publication
1995
Pages
69 - 75
Database
ISI
SICI code
0165-7992(1995)346:2<69:AOEITR>2.0.ZU;2-9
Abstract
The antimutagenic effect of eugenol on the mutagenicity of cyclophosph amide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[ a]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus t est using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency o f micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a ]P. The results provide some support for antimutagenic potency of euge nol in vivo.