After the 1990 establishment of a multidisciplinary foot salvage clini
c, 1346 diabetic patients, at high risk for the development of foot ul
cers and eventual lower limb amputation, were followed for 4 years. Of
the 224 high-risk patients admitted to the hospital, 74 amputations (
5.5%) of all or part of a lower limb were performed. Patients undergoi
ng amputation were younger, more severely ill, and required more frequ
ent hospitalizations because of greater organ system involvement. They
were also more likely to be institutionalized after discharge. Overal
l, patients with long-standing adult-onset diabetes, identified as at
high risk for foot ulcer development, have a substantially increased r
isk for lower limb amputation, multiple organ system failure, hospital
ization, and institutionalization than do diabetic patients as a whole
. Clinical benchmarking facilitates the identification and reduction o
f unnecessary variations in patient care practices. Here, a formal ben
chmark analysis provides the current outcome expectations for amputati
on rates and co-morbidities in patients with diabetes who are classifi
ed as at high risk for lower extremity amputation. Management of these
patients in a structured, multidisciplinary foot salvage clinic, augm
entation of baseline services, and preliminary benchmark data may prov
ide a standard for the measurement of therapeutic interventions that i
mprove patient care.