Pb. Carrieri et al., EVALUATION OF INTERLEUKIN-10 AND INTERFERON-ALPHA IN THE CEREBROSPINAL-FLUID AND SERUM OF PATIENTS WITH MULTIPLE-SCLEROSIS, European journal of neurology, 3(6), 1996, pp. 544-547
The activities of IL-10, a cytokine produced by TH2 cells, monocytes a
nd B-cells, and IFN-alpha, a product of activated macrophages/monocyte
s, were investigated in the CSF and serum samples of 25 subjects with
clinically definite multiple sclerosis (MS), of whom 14 were in the ac
tive and nine in the stable phase, and of 15 controls with other nonin
flammatory neurological diseases (OND). Elevated CSF IL-10 and IFN-alp
ha levels were found in MS patients in the stable phase with respect t
o patients in the active phase (p < 0.001), while no significant diffe
rences were observed in the mean serum levels between IL-10 patients (
both in the active and stable phase) and controls. Finally, a signific
ant correlation was detected between IL-10 and IFN-alpha in the CSP of
MS patients in remission. This study suggests that IL-10 may downregu
late MS progression.