PHARMACOKINETICS AND DOSING REGIMEN OF AMINOSIDINE IN THE DOG

The kinetic behaviour of the aminoglycoside aminosidine, given at 15 m g/kg intravenously, intramuscularly and subcutaneously, was studied in 5 dogs to determine the appropriate dosage schedule. The pharmacokine tic behaviour of aminosidine in dogs was similar to that in other spec ies, except that it was eliminated more slowly (beta=0.007+/-0.0003 mi n(-1)). Intramuscular and subcutaneous administration produced peak se rum concentrations (C-max?([in])=32+/-6.4 mu g/ml; C-max[sc]=36+/-3.4 mu g/ml) and times to peak concentration (T-max=60 min for both) that did not differ significantly; and neither compartmental nor non-compar tmental analysis revealed any significant differences between any of t he kinetic parameters obtained for these two extravenous routes of adm inistration. Comparison of these results with previously published dat a suggests that aminosidine given once daily at 15 mg/kg would be as e ffective as, and safer than, the two or three daily administrations co mmonly employed in dogs.