MIDLATENCY AUDITORY-EVOKED POTENTIALS AS INDICATORS OF PERCEPTUAL PROCESSING DURING GENERAL-ANESTHESIA

We tested the hypothesis that midlatency auditory evoked potentials (M LAEP) can predict the occurrence of long latency AEP components (LLAEP ), which are taken as evidence for perceptual processing. Forty-one pa tients undergoing cardiac surgery were anaesthetized with propofol and alfentanil. During several periods of surgery we recorded LLAEP. Peak -to-peak amplitude measures were used to determine if a particular LLA EP recording trace contained a recognizable waveform. Both before and after each LLAEP recording epoch, MLAEP and the spontaneous electroenc ephalogram (EEG) were recorded. Peak latencies and amplitudes of brain stem peak V and midlatency peaks Na, Pa, Nb, Pb and Nc, characteristic frequencies from the spontaneous EEG, mean arterial pressure (MAP) an d nasopharyngeal temperature (T) were compared between recording epoch s with and without clear LLAEP waveforms. These variables were also us ed in a discriminant analysis to predict the occurrence of an LLAEP wa veform. Pa and Nb latencies were significantly shorter both before and after recording epochs in which an LLAEP waveform occurred, compared with epochs in which no LLAEP waveform occurred, Using a combination o f up to six EEG, MLAEP, MAP and T measures, it was possible to predict the occurrence or absence of an LLAEP waveform with a sensitivity of 89% and specificity of 86%. We conclude that MLAEP components provide information on the possibility of perceptual processing during general anaesthesia, and thus may be relevant for monitoring depth of anaesth esia.