We have examined a new approach, using fuzzy logic, to the closed-loop
feedback control of mechanical ventilation during general anaesthesia
. This control system automatically adjusts ventilatory frequency (f)
and tidal volume (V-T) in order to achieve and maintain the end-tidal
carbon dioxide fraction (FE'(CO2)) at a desired level (set-point). The
controller attempts to minimize the deviation of both f and V-T per k
g body weight from 10 bpm and 10 ml kg(-1), respectively, and to maint
ain the plateau airway pressure within suitable limits. in 30 patients
, undergoing various surgical procedures, the fuzzy control mode was c
ompared with human ventilation control, For a set-point of FE'(CO2) =
4.5 vol% and during measurement periods of 20 min, accuracy, stability
and breathing pattern did not differ significantly between fuzzy logi
c and manual ventilation control. After step-changes in the set-point
of FE'(CO2) from 4.5 to 5.5 vol% and vice versa, overshoot and rise ti
me did not differ significantly between the two control modes. We conc
lude that to achieve and maintain a desired FE'(CO2) during routine an
aesthesia, fuzzy logic feedback control of mechanical ventilation is a
reliable and safe mode of control.